An opportunity of a lifetime?

How would you define an opportunity of a lifetime? Starting your own company? Making a successful career transition? Having a family? Leaving clinical medicine? Getting married? Becoming an entrepreneur?

Maybe you've recently been faced with a few scenarios that you would describe as potential "opportunities of a lifetime." Are you willing to take some risks? I'm generally a fairly risk-adverse type of person, but I've been listening to some great business podcasts from iTunes U (the U is for University) and I've been inspired to take some risks in my life.

These are exciting times given that we're going t see some significant advances in medical technology and adoption in health IT will increase dramatically. As our nation goes through health care reform, new challenges will also mean new opportunities for those who are creative and who are forward-thinking.