What will happen to all those patients on coumadin (warfarin) if we get a new pill that requires no INR monitoring? Well, rivaroxaban (Xarelto®) may be that first pill in the USA. Rivaroxaban has been submitted for FDA approval. It acts by inhibiting factor Xa, so there is no INR to check since it does not work like warfarin (that inhibits vitamin K-dependent clotting factors).
What will happen to all those Coumadin clinics out there? What about all those fingerstick INR machines? Labs processing those weekely INR checks?
There was a lot of excitement several years ago with the development of Ximelagatran (Exanta). Live toxicity ended the development of that drug in the USA.
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